Learning outcomes of the MSc

• Basic principles of stem cell biology and the factors that affect their growth/proliferation and specialization.
• Biomaterials and their applications in regenerative medicine
• Modern laboratory techniques and development of research skills
• In silico study and bioinformatics,
• Operation of a laboratory active in stem cell applications, especially in the field

Course Information

From zygote to man

Understanding the development of the fetus.
Knowledge of the factors and mechanisms that promote the proliferation and differentiation of cells from the almighty zygote to the specialized monovalent cell of the tissue to complete the creation of organs.

Stem Cell Biology

Familiarization of students with the specialized characteristics of different types of stem cells.
Understanding the biological properties of stem cells.
Acquaintance with medical applications and perspectives in the context of regenerative medicine.
In particular, the potential for tissue and organ creation and the development of new therapeutic approaches

Biomaterials-Scaffolding

Knowledge of different kinds of biomaterials.
Understanding of their specific properties and their interaction with cells.
Modern medical applications and prospects of biomaterials.

Contemporary laboratory techniques

Acquaintance and understanding of modern laboratory techniques used in fundamental biochemical and molecular research of stem cells. Appropriate theoretical background to understand the results of scientific publications.
Formulating a research question and selecting appropriate techniques and methods for its investigation.

Bioinformatics

Familiarization of students with the concepts and algorithms of bioinformatics.
Use of specific ones with emphasis on algorithms used in bioinformatics.
Understand how programs work and configure their parameters to get the best result each time.

Laboratory practice in Regenerative Medicine

• Ways to check the appropriate conditions of the laboratory room.
• Collection, isolation, and characterization of cell populations
• Cell proliferation – bioreactors
• Cryofreezing and preservation
• Defrost and release.
• Quality control of biomedical products,
• ex vivo cell differentiation
• genetic modification
• Creation of instruments in the laboratory.
• Examples of modern clinical applications (e.g., skin, chondrocytes).

Stem cells in surgical specialties

• General surgery
• Urology,
• Cardiac surgery (regeneration of lung, heart, and vessels)
• Plastic surgery
• Gynecology
• Neurosurgery
• Gastroenterology
• Interventional radiology.

Research Methodology

• Understanding how research studies are designed.
• Learning to record and evaluate results properly.
• The perception of specific processes and techniques used to identify, select, process, and analyze information and results on a research topic.
• The cultivation of critical thinking for evaluating a research process in terms of its validity and reliability.
• The acquisition of knowledge for proper design until the completion and publication of a scientific paper.
• The connection, networking, and promotion of research results.

From research to clinical practice

Understand how a research product can be tested on suitable patients to establish its safety and efficacy and obtain marketing authorization for human use. The ethical, philosophical, and economic implications of widespread uses of such products.
There is a need for long-term monitoring strategies for the safety and effectiveness of treatments for the patient receiving them and their immediate and broader social environment.

Immunology and transplantation

Knowledge about the tissues and organs of the immune system (primary and secondary lymphatic organs)
Cells of natural or innate immunity, cells of the immune system
The histocompatibility system (HLA)
Immune response, regulatory mechanisms involved.
the role of stem cells in the study and treatment of autoimmune diseases,
Hematopoietic cell immunology and transplantation.
Immune response to mesenchymal cells and its regulation.

Stem cells and degenerative diseases

The latest developments regarding the role of stem cells in the treatment of cardiovascular, hematological, rheumatological, neurological, and ophthalmological diseases.
Reference is made to treating diabetes mellitus and gastroenterological and pulmonary diseases.
Finally, ways of treating oncological diseases are presented.

Regenerative Medicine and Rehabilitation

Use of stem cells and their applications in Regenerative Medicine in various clinical specialties with emphasis on Dermatology, Plastic Surgery, and Orthopedics.
The types of stem cells used in clinical practice are presented in detail depending on the specialty and their various therapeutic applications.
References to applications related to the treatment of osteoarthritis, fracture, intervertebral disc repair, bone grafts, use for cartilage scaffolding production for ear and nose rehabilitation, burn, face, scar, wound repair, skin healing, and anti-aging applications.